Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story
نویسندگان
چکیده
منابع مشابه
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
African trypanosomes cause sleeping sickness in humans, a disease that is typically fatal without chemotherapy. Unfortunately, drug resistance is common and melarsoprol-resistant trypanosomes often display cross-resistance to pentamidine. Although melarsoprol/pentamidine cross-resistance (MPXR) has been an area of intense interest for several decades, our understanding of the underlying mechani...
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ژورنال
عنوان ژورنال: Trends in Parasitology
سال: 2013
ISSN: 1471-4922
DOI: 10.1016/j.pt.2012.12.005